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DOI:10.1111/trf.12264 - Corpus ID: 4666359
@article{Zimring2014StrainspecificRB, title={Strain‐specific red blood cell storage, metabolism, and eicosanoid generation in a mouse model}, author={James C. Zimring and Nicole H. Smith and Sean R. Stowell and Jill M. Johnsen and Lauren N. Bell and Richard O. Francis and Eldad A. Hod and Jeanne Elise Hendrickson and John D. Roback and Steven L. Spitalnik}, journal={Transfusion}, year={2014}, volume={54}, url={https://api.semanticscholar.org/CorpusID:4666359}}
- J. Zimring, Nicole H. Smith, S. Spitalnik
- Published in Transfusion 1 January 2014
- Biology, Medicine
Red blood cell (RBC) transfusion is a lifesaving therapy, the logistic implementation of which requires RBC storage. However, stored RBCs exhibit substantial donor variability in multiple…
86 Citations
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86 Citations
- Ariel M. HayH. L. HowieH. WatermanKaren de WolskiJ. Zimring
- 2017
Biology, Medicine
Transfusion
A strain of mice with RBCs known to store well (B6) and a strain known to Store poorly (FVB) were utilized to test the hypothesis that RBC’s affected the storage of other R BCs.
- 9
- PDF
- A. D’AlessandroA. GrayZ. SzczepiorkowskiK. HansenL. HerschelL. Dumont
- 2017
Medicine
Transfusion
The aim of this study is to determine the metabolic changes in stored RBCs over 42 days of routine storage followed by a US Food and Drug Administration‐approved method of rejuvenation, freezing, and preparation for transfusion.
- 53
- PDF
- Robert B. NeumanS. Hayek J. Roback
- 2015
Medicine
Transfusion
Clinical and animal studies indicate that transfusions of older stored red blood cells (RBCs) impair clinical outcomes as compared to fresh RBC transfusions. It has been suggested that this effect is…
- 39
- PDF
- Deborah ChenP. SchubertD. Devine
- 2017
Biology, Medicine
Transfusion
This work aimed to decipher relevant donor characteristics that may predict red blood cell (RBC) quality during storage using a proteomic approach.
- 12
- T. KaniasD. Sinchar M. Gladwin
- 2016
Biology, Medicine
Transfusion
Red blood cell (RBC) hemolysis represents an intrinsic mechanism for human vascular disease and genetic and population modifiers of Hemolysis, including sex, have not been established.
- 123
- Highly Influenced
- PDF
- Xiaoyun FuJacob R. FelcynK. Odem-DavisJ. Zimring
- 2016
Chemistry, Medicine
Transfusion
Accumulation of bioactive lipids during red blood cell storage has been identified as a potential source of posttransfusion sequelae in vulnerable populations and leukoreduction has been seen as a solution to this issue.
- 54
- A. D’AlessandroT. Nemkov K. Hansen
- 2015
Medicine
Transfusion
It is hypothesize that, despite reported beneficial effects, storage in AS‐3 results in metabolic impairment weeks before the end of the unit shelf life.
- 119
- PDF
- R. PatelJ. RobackK. UppalTianwei YuDean P. JonesC. Josephson
- 2015
Chemistry, Medicine
Transfusion
Understanding the metabolites that are altered by donor red blood cell (RBC) storage and irradiation may provide insight into the metabolic pathways disrupted by the RBC storage lesion.
- 50
- PDF
- E. HogervorstR. MiddelburgA. BrandL. Van De WateringH. Schonewille
- 2015
Medicine
Transfusion
This study aims to quantify the association of anti-K formation with RBC storage time and identifies the K+ RBC unit that triggered anti‐K formation and determination of its storage time.
- 6
- A. D’AlessandroT. NemkovK. HansenZ. SzczepiorkowskiL. Dumont
- 2015
Chemistry, Medicine
Transfusion
It is hypothesize that AS‐7 might exert its beneficial effects through metabolic modulation during routine storage through the implementation of novel additive solutions that tackle the accumulation of biochemical and morphologic lesion during routine cold liquid storage in the blood bank.
- 72
- PDF
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32 References
- Christopher R. GilsonTeresa S. Kraus J. Zimring
- 2009
Biology, Medicine
Transfusion
A mouse model of RBC storage and transfusion was developed to assess survival kinetics of mouse RBCs and it has been reported that storage of rat R BCs in CPDA‐1 resulted in an unexpected sudden decline in posttransfusion survival.
- 114
- Highly Influential
- PDF
- L. van de Watering
- 2011
Medicine
Vox sanguinis
An overview of the conflicting literature on the clinical relevance of prolonged storage is given, summarizing the evidence on associations with mortality, length of stay, (postoperative) infections and organ failure.
- 143
- PDF
- R. ObradorSarah E MusulinB. Hansen
- 2015
Medicine
Journal of veterinary emergency and critical care
Most reports in the human and veterinary literature support the concept that there are deleterious effects of the RBC storage lesion, but additional studies with improved experimental design are needed to identify compelling reasons to modify current blood banking and transfusion practices.
- 121
- J. Hess
- 2010
Medicine
Journal of proteomics
- 143
- E. HodNing Zhang S. Spitalnik
- 2010
Medicine
Blood
Results suggest that, in a mouse model, the cellular component of leukoreduced, stored RBC units contributes to the harmful effects of RBC transfusion that occur after prolonged storage, which must be confirmed by prospective human studies.
- 463
- PDF
- C. SillimanErnest E. MooreM. KelherSamina Y. KhanL. GellarDavid J. Elzi
- 2011
Medicine
Transfusion
It is hypothesized that prestorage leukoreduction changes the classes of lipids that accumulate during storage, and these lipids prime PMNs and induce acute lung injury (ALI) as the second event in a two‐event in vivo model.
- 172
- PDF
- J. Hess
- 2010
Medicine
Transfusion and apheresis science : official…
- 267
- Highly Influential
- E. HodS. Spitalnik
- 2011
Medicine
Transfusion
The overarching hypothesis is that the adverse effects associated with transfusion of older, stored RBCs result from the acute delivery of hemoglobin iron to the monocyte‐macrophage system, and the goal is to determine the mechanism(s) for this potential effect.
- 74
- PDF
- J. TissotOlivier RubinG. Canellini
- 2010
Medicine
Current opinion in hematology
Purpose of reviewThe mechanisms involved in the formation of red blood cell (RBC) microparticles in vivo as well as during erythrocyte storage are reviewed, and the potential role of microparticles…
- 92
- E. HodS. Spitalnik
- 2012
Medicine
Transfusion clinique et biologique : journal de…
- 107
- PDF
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