[PDF] Strain‐specific red blood cell storage, metabolism, and eicosanoid generation in a mouse model | Semantic Scholar (2025)

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@article{Zimring2014StrainspecificRB, title={Strain‐specific red blood cell storage, metabolism, and eicosanoid generation in a mouse model}, author={James C. Zimring and Nicole H. Smith and Sean R. Stowell and Jill M. Johnsen and Lauren N. Bell and Richard O. Francis and Eldad A. Hod and Jeanne Elise Hendrickson and John D. Roback and Steven L. Spitalnik}, journal={Transfusion}, year={2014}, volume={54}, url={https://api.semanticscholar.org/CorpusID:4666359}}
  • J. Zimring, Nicole H. Smith, S. Spitalnik
  • Published in Transfusion 1 January 2014
  • Biology, Medicine

Red blood cell (RBC) transfusion is a lifesaving therapy, the logistic implementation of which requires RBC storage. However, stored RBCs exhibit substantial donor variability in multiple

86 Citations

Background Citations

23

Methods Citations

5

Results Citations

6

86 Citations

Murine red blood cells from genetically distinct donors cross‐regulate when stored together
    Ariel M. HayH. L. HowieH. WatermanKaren de WolskiJ. Zimring

    Biology, Medicine

    Transfusion

  • 2017

A strain of mice with RBCs known to store well (B6) and a strain known to Store poorly (FVB) were utilized to test the hypothesis that RBC’s affected the storage of other R BCs.

  • 9
  • PDF
Red blood cell metabolic responses to refrigerated storage, rejuvenation, and frozen storage
    A. D’AlessandroA. GrayZ. SzczepiorkowskiK. HansenL. HerschelL. Dumont

    Medicine

    Transfusion

  • 2017

The aim of this study is to determine the metabolic changes in stored RBCs over 42 days of routine storage followed by a US Food and Drug Administration‐approved method of rejuvenation, freezing, and preparation for transfusion.

Effects of storage‐aged red blood cell transfusions on endothelial function in hospitalized patients
    Robert B. NeumanS. Hayek J. Roback

    Medicine

    Transfusion

  • 2015

Clinical and animal studies indicate that transfusions of older stored red blood cells (RBCs) impair clinical outcomes as compared to fresh RBC transfusions. It has been suggested that this effect is

  • 39
  • PDF
Proteomic analysis of red blood cells from donors exhibiting high hemolysis demonstrates a reduction in membrane‐associated proteins involved in the oxidative response
    Deborah ChenP. SchubertD. Devine

    Biology, Medicine

    Transfusion

  • 2017

This work aimed to decipher relevant donor characteristics that may predict red blood cell (RBC) quality during storage using a proteomic approach.

  • 12
Testosterone‐dependent sex differences in red blood cell hemolysis in storage, stress, and disease
    T. KaniasD. Sinchar M. Gladwin

    Biology, Medicine

    Transfusion

  • 2016

Red blood cell (RBC) hemolysis represents an intrinsic mechanism for human vascular disease and genetic and population modifiers of Hemolysis, including sex, have not been established.

  • 123
  • Highly Influenced
  • PDF
Bioactive lipids accumulate in stored red blood cells despite leukoreduction: a targeted metabolomics study
    Xiaoyun FuJacob R. FelcynK. Odem-DavisJ. Zimring

    Chemistry, Medicine

    Transfusion

  • 2016

Accumulation of bioactive lipids during red blood cell storage has been identified as a potential source of posttransfusion sequelae in vulnerable populations and leukoreduction has been seen as a solution to this issue.

  • 54
Routine storage of red blood cell (RBC) units in additive solution‐3: a comprehensive investigation of the RBC metabolome
    A. D’AlessandroT. Nemkov K. Hansen

    Medicine

    Transfusion

  • 2015

It is hypothesize that, despite reported beneficial effects, storage in AS‐3 results in metabolic impairment weeks before the end of the unit shelf life.

  • 119
  • PDF
Metabolomics profile comparisons of irradiated and nonirradiated stored donor red blood cells
    R. PatelJ. RobackK. UppalTianwei YuDean P. JonesC. Josephson

    Chemistry, Medicine

    Transfusion

  • 2015

Understanding the metabolites that are altered by donor red blood cell (RBC) storage and irradiation may provide insight into the metabolic pathways disrupted by the RBC storage lesion.

  • 50
  • PDF
Anti‐K formation is not associated with the storage time of transfused red blood cells
    E. HogervorstR. MiddelburgA. BrandL. Van De WateringH. Schonewille

    Medicine

    Transfusion

  • 2015

This study aims to quantify the association of anti-K formation with RBC storage time and identifies the K+ RBC unit that triggered anti‐K formation and determination of its storage time.

  • 6
Red blood cell storage in additive solution‐7 preserves energy and redox metabolism: a metabolomics approach
    A. D’AlessandroT. NemkovK. HansenZ. SzczepiorkowskiL. Dumont

    Chemistry, Medicine

    Transfusion

  • 2015

It is hypothesize that AS‐7 might exert its beneficial effects through metabolic modulation during routine storage through the implementation of novel additive solutions that tackle the accumulation of biochemical and morphologic lesion during routine cold liquid storage in the blood bank.

  • 72
  • PDF

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32 References

A novel mouse model of red blood cell storage and posttransfusion in vivo survival
    Christopher R. GilsonTeresa S. Kraus J. Zimring

    Biology, Medicine

    Transfusion

  • 2009

A mouse model of RBC storage and transfusion was developed to assess survival kinetics of mouse RBCs and it has been reported that storage of rat R BCs in CPDA‐1 resulted in an unexpected sudden decline in posttransfusion survival.

  • 114
  • Highly Influential
  • PDF
Red cell storage and prognosis
    L. van de Watering

    Medicine

    Vox sanguinis

  • 2011

An overview of the conflicting literature on the clinical relevance of prolonged storage is given, summarizing the evidence on associations with mortality, length of stay, (postoperative) infections and organ failure.

  • 143
  • PDF
Red blood cell storage lesion.
    R. ObradorSarah E MusulinB. Hansen

    Medicine

    Journal of veterinary emergency and critical care

  • 2015

Most reports in the human and veterinary literature support the concept that there are deleterious effects of the RBC storage lesion, but additional studies with improved experimental design are needed to identify compelling reasons to modify current blood banking and transfusion practices.

  • 121
Red cell storage.
    J. Hess

    Medicine

    Journal of proteomics

  • 2010
  • 143
Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation.
    E. HodNing Zhang S. Spitalnik

    Medicine

    Blood

  • 2010

Results suggest that, in a mouse model, the cellular component of leukoreduced, stored RBC units contributes to the harmful effects of RBC transfusion that occur after prolonged storage, which must be confirmed by prospective human studies.

  • 463
  • PDF
Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injury
    C. SillimanErnest E. MooreM. KelherSamina Y. KhanL. GellarDavid J. Elzi

    Medicine

    Transfusion

  • 2011

It is hypothesized that prestorage leukoreduction changes the classes of lipids that accumulate during storage, and these lipids prime PMNs and induce acute lung injury (ALI) as the second event in a two‐event in vivo model.

  • 172
  • PDF
Red cell changes during storage.
    J. Hess

    Medicine

    Transfusion and apheresis science : official…

  • 2010
  • 267
  • Highly Influential
Harmful effects of transfusion of older stored red blood cells: iron and inflammation
    E. HodS. Spitalnik

    Medicine

    Transfusion

  • 2011

The overarching hypothesis is that the adverse effects associated with transfusion of older, stored RBCs result from the acute delivery of hemoglobin iron to the monocyte‐macrophage system, and the goal is to determine the mechanism(s) for this potential effect.

  • 74
  • PDF
Analysis and clinical relevance of microparticles from red blood cells
    J. TissotOlivier RubinG. Canellini

    Medicine

    Current opinion in hematology

  • 2010

Purpose of reviewThe mechanisms involved in the formation of red blood cell (RBC) microparticles in vivo as well as during erythrocyte storage are reviewed, and the potential role of microparticles

  • 92
Stored red blood cell transfusions: Iron, inflammation, immunity, and infection.
    E. HodS. Spitalnik

    Medicine

    Transfusion clinique et biologique : journal de…

  • 2012
  • 107
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